Publikationen

Ausgewählte Publikationen unserer Arbeitsgruppe. Die vollständige Publikationsliste finden Sie auf unserem PubMed-Profil.

Preprintsnot yet peer-reviewed

Preprint · not peer-reviewed

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

Senger F, Hille SS, Remes AK, Baral TK, Martin-Garrido A, Schmiedel N, Kuhn C, Müller OJ, Rangrez AY, Backs J, Beisaw A, Heineke J, Frey N (2026). bioRxiv (preprint).

DOI: 10.64898/2026.03.17.712297

Preprint · not peer-reviewed

Multicellular signaling and partial recovery define reverse cardiac remodeling

Steier M, Rivero-Garcia I, Ramirez Flores RO, Deshpande A, Poetzsch J, Nazir S, Aijaz I, Talamini M, Ast V, Mößinger K, Dewenter M, Meder B, Kumari M, Backs J, Rangrez AY, Saez-Rodriguez J, Frey N (2026). bioRxiv (preprint).

DOI: 10.64898/2026.01.12.699040

2026

Strip1 Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

Heilein E, Kilian LS, Sossalla S, Meder B, Völkers M, Frese KS, Herch S, Frey N, Eden M (2026). Cells.

DOI: 10.3390/cells15060540

2025

A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling

Lanzer JD, Ramirez Flores RO, Liñares Blanco J, Steier M, Rangrez AY, Frey N, Saez-Rodriguez J (2025). Nat Commun.

DOI: 10.1038/s41467-025-62219-6

Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo

Martini S, Dobberstein I, Schmiedel N, Kilian LS, Voran JC, Senger F, Rangrez AY, Frank D, Kuhn C, Frey N (2025). Front Cell Dev Biol.

DOI: 10.3389/fcell.2025.1661965

Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes

Deshpande A, Weirauch L, Baral TK, Steier M, Borlepawar A, Kumari M, Kilian LS, Richter K, Hammer E, Frank D, Schmidt C, Frey N, Rangrez AY (2025). Cell Commun Signal.

DOI: 10.1186/s12964-025-02378-7

AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model

Kliesow Remes A, ..., Frank D, Frey N, Müller OJ (2025). Basic Res Cardiol.

DOI: 10.1007/s00395-025-01123-y

2024

Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy

Eden M, Leye M, Hahn J, Heilein E, Luzarowski M, Völschow B, Tannert C, Sossalla S, Lucena-Porcel C, Frank D, Frey N (2024). J Biol Chem.

DOI: 10.1016/j.jbc.2024.107255

2023

Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo

Petersen M, Schmiedel N, Dierck F, Hille S, Remes A, Senger F, Schmidt I, Lüllmann-Rauch R, Müller OJ, Frank D, Rangrez AY, Frey N, Kuhn C (2023). Front Mol Biosci.

DOI: 10.3389/fmolb.2023.1169658

2021

Cardiac Filaminopathies: Illuminating the Divergent Role of Filamin C Mutations in Human Cardiomyopathy

Eden M, Frey N (2021). J Clin Med.

DOI: 10.3390/jcm10040577

FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo

Kuhn C, Menke M, Senger F, Mack C, Dierck F, Hille S, Schmidt I, Brunke G, Bünger P, Schmiedel N, Will R, Sossalla S, Frank D, Eschenhagen T, Carrier L, Lüllmann-Rauch R, Rangrez AY, Frey N (2021). JACC Basic Transl Sci.

DOI: 10.1016/j.jacbts.2021.01.001

SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes

Deshpande A, Borlepawar A, Rosskopf A, Frank D, Frey N, Rangrez AY (2021). Int J Mol Sci.

DOI: 10.3390/ijms222011042

2020

Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice

Borlepawar A, ..., Eden M, ..., Frey N, Rangrez AY (2020). Cells.

DOI: 10.3390/cells9112390

2016

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Eden M, ..., Hofmann F, Frey N (2016). Nat Commun.

DOI: 10.1038/ncomms11317

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy

Bernt A, Rangrez AY, Eden M, ..., Frank D, Frey N (2016). Sci Rep.

DOI: 10.1038/srep35758

Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and β-Catenin/GSK-3β Protein Signaling

Rangrez AY, Eden M, ..., Frank D, Frey N (2016). J Biol Chem.

DOI: 10.1074/jbc.M115.689620

2014

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy

Frank D, Rangrez AY, ..., Eden M, ..., Frey N (2014). J Mol Cell Cardiol.

DOI: 10.1016/j.yjmcc.2014.03.016

2010

Myomasp/LRRC39, a Heart- and Muscle-Specific Protein, Is a Novel Component of the Sarcomeric M-Band and Is Involved in Stretch Sensing

Will RD, Eden M, ..., Frank D, ..., Frey N (2010). Circ Res.

DOI: 10.1161/CIRCRESAHA.110.222372

2008

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation

Frey N, Frank D, ..., Katus HA, Olson EN (2008). J Clin Invest.

DOI: 10.1172/JCI36277

2004

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

Frey N, ..., Katus HA, ..., Olson EN (2004). Nat Med.

DOI: 10.1038/nm1132

2000

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

Frey N, Richardson JA, Olson EN (2000). Proc Natl Acad Sci USA.

DOI: 10.1073/pnas.260501097

Vollständige Publikationsliste auf PubMed einsehen PubMed-Profil