Our research investigates intracellular signaling pathways that regulate cardiac hypertrophy and heart failure, aiming to identify novel therapeutic targets.
From the T-tubule network of the cardiomyocyte to the cryo-EM structure of the STRIPAK core.
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ANEPPS · 40× · cyan LUT
01 · Cell
Where excitation becomes contraction.
We investigate how cardiomyocytes sense mechanical load and translate it into cellular responses.
Stretch sensing · EC coupling · T-tubule · Filamin C
T-tubule network, ANEPPS membrane stain, 40×. Original red, shown here in a monotone cyan LUT. Eden / Frey Lab.
5 nmPDB 7K36 · cryo-EM 3.3 Å
02 · Complex
STRIPAK, resolved at the molecular level.
We identified Myoscape (STRIP2) as a cardiac-specific component of the STRIPAK complex (Eden et al., Nat Commun 2016). The structure of the human core shows STRIP1 together with striatin-3, MOB4 and PP2A.
PDB 7K36 · Jeong et al., Nat Struct Mol Biol 2021 (doi). Rendered by the Eden / Frey Lab, orthographic projection.
01Cell
02Complex
Research Focus
Four areas of molecular cardiology research
We combine molecular biology, phosphoproteomics, and advanced cardiomyocyte models to understand disease mechanisms and identify novel therapeutic targets.
Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1alpha inhibition and drives heart failure
Kumari M, Evangelakos I, Deshpande A, De Jong KA, Schmiedel N, Palacio-Escat N, Chaves-Filho AB, Frias-Soler RC, Klinke G, Roh HC, Lange L, Berlin M, Fuh MM, Buss JJ, Tian T, Lerchenmüller C, Freichel M, Schulze A, Nikolaev VO, Eschenhagen T, Rosen ED, Scheja L, Rangrez AY, Heeren J, Frey N
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