Molecular Cardiology · AG Eden / FreyDepartment of Internal Medicine III · Cardiology, Angiology and Pneumology
AG Eden / Frey

Publications

Basic-science publications of the Eden/Frey lab, newest first. Every entry is checked against PubMed, Crossref or bioRxiv; clinical publications are listed on PubMed.

32 lab-led original articles

Counted are basic-science original articles with Norbert Frey or Matthias Eden as first, last or corresponding author, and articles led by group leaders from the lab with Norbert Frey as penultimate author. Collaborations, reviews and preprints are listed but not counted.

2026

  1. MedComm · 2026Review

    Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

    García Torres JE, Frey N, Rangrez AY

    DOI: 10.1002/mco2.70892PMID: 42571123

  2. Signal Transduct Target Ther · 2026Review

    Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases

    Borlepawar A, Neu M, Ma Z, Deshpande A, Bühringer H, Hajieva P, Frey N, Rangrez AY

    DOI: 10.1038/s41392-026-02714-4PMID: 42259777

  3. Cells · 2026

    Strip1 Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

    Heilein E, Kilian LS, Sossalla S, Meder B, Völkers M, Frese KS, Herch S, Frey N, Eden M

    DOI: 10.3390/cells15060540PMID: 41892331

  4. bioRxiv · 2026Preprint · not peer-reviewed

    FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

    Senger F, Hille SS, Kliesow Remes A, Baral TK, Martin-Garrido A, Schmiedel N, Kuhn C, Müller OJ, Rangrez AY, Backs J, Beisaw A, Heineke J, Frey N

    DOI: 10.64898/2026.03.17.712297

  5. Nat Commun · 2026

    Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1alpha inhibition and drives heart failure

    Kumari M, Evangelakos I, Deshpande A, De Jong KA, Schmiedel N, Palacio-Escat N, Chaves-Filho AB, Frias-Soler RC, Klinke G, Roh HC, Lange L, Berlin M, Fuh MM, Buss JJ, Tian T, Lerchenmüller C, Freichel M, Schulze A, Nikolaev VO, Eschenhagen T, Rosen ED, Scheja L, Rangrez AY, Heeren J, Frey N

    DOI: 10.1038/s41467-026-69792-4PMID: 41760613

  6. bioRxiv · 2026Preprint · not peer-reviewed

    Multicellular signaling and partial recovery define reverse cardiac remodeling

    Steier M, Rivero-Garcia I, Flores ROR, Deshpande A, Poetzsch J, Nazir S, Aijaz I, Talamini M, Ast V, Mößinger K, Dewenter M, Meder B, Kumari M, Backs J, Rangrez AY, Saez-Rodriguez J, Frey N

    DOI: 10.64898/2026.01.12.699040

2025

  1. Front Cell Dev Biol · 2025

    Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo

    Martini S, Dobberstein I, Schmiedel N, Kilian LS, Voran JC, Senger F, Rangrez AY, Frank D, Kuhn C, Frey N

    DOI: 10.3389/fcell.2025.1661965PMID: 41293419

  2. Nat Commun · 2025Collaboration

    A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling

    Lanzer JD, Ramirez Flores RO, Liñares Blanco J, Steier M, Rangrez AY, Frey N, Saez-Rodriguez J

    DOI: 10.1038/s41467-025-62219-6PMID: 41173856

  3. Cell Commun Signal · 2025

    Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes

    Deshpande A, Weirauch L, Baral TK, Steier M, Borlepawar A, Kumari M, Kilian LS, Richter K, Hammer E, Frank D, Schmidt C, Frey N, Rangrez AY

    DOI: 10.1186/s12964-025-02378-7PMID: 40849623

  4. Basic Res Cardiol · 2025Collaboration

    AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model

    Kliesow Remes A, Ruf T, Zurashvili T, Ding L, Meyer-Jens M, Schwab DM, Hille S, Matzen A, Michalewski S, Kilian L, Shetty PMV, Fuchs MC, Eden M, Gröne HJ, Rapti K, Jungmann A, Milting H, Katus HA, Carrier L, Frank D, Frey N, Müller OJ

    DOI: 10.1007/s00395-025-01123-yPMID: 40646338

2024

  1. J Biol Chem · 2024

    Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy

    Eden M, Leye M, Hahn J, Heilein E, Luzarowski M, Völschow B, Tannert C, Sossalla S, Lucena-Porcel C, Frank D, Frey N

    DOI: 10.1016/j.jbc.2024.107255PMID: 38579991

2023

  1. Front Mol Biosci · 2023

    Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo

    Petersen M, Schmiedel N, Dierck F, Hille S, Remes A, Senger F, Schmidt I, Lüllmann-Rauch R, Müller OJ, Frank D, Rangrez AY, Frey N, Kuhn C

    DOI: 10.3389/fmolb.2023.1169658PMID: 37342207

2022

2021

  1. Int J Mol Sci · 2021

    SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes

    Deshpande A, Borlepawar A, Rosskopf A, Frank D, Frey N, Rangrez AY

    DOI: 10.3390/ijms222011042PMID: 34681711

  2. JACC Basic Transl Sci · 2021

    FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo

    Kuhn C, Menke M, Senger F, Mack C, Dierck F, Hille S, Schmidt I, Brunke G, Bünger P, Schmiedel N, Will R, Sossalla S, Frank D, Eschenhagen T, Carrier L, Lüllmann-Rauch R, Rangrez AY, Frey N

    DOI: 10.1016/j.jacbts.2021.01.001PMID: 33997522

2020

  1. Cells · 2020

    Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice

    Borlepawar A, Schmiedel N, Eden M, Christen L, Rosskopf A, Frank D, Lüllmann-Rauch R, Frey N, Rangrez AY

    DOI: 10.3390/cells9112390PMID: 33142804

  2. Commun Biol · 2020

    The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice

    Rangrez AY, Borlepawar A, Schmiedel N, Deshpande A, Remes A, Kumari M, Bernt A, Christen L, Helbig A, Jungmann A, Sossalla S, Tholey A, Müller OJ, Frank D, Frey N

    DOI: 10.1038/s42003-020-01289-2PMID: 33037313

2019

  1. Biochem Biophys Res Commun · 2019

    A cardiac alpha-actin (ACTC1) p. Gly247Asp mutation inhibits SRF-signaling in vitro in neonatal rat cardiomyocytes

    Rangrez AY, Kilian L, Stiebeling K, Dittmann S, Schulze-Bahr E, Frey N, Frank D

    DOI: 10.1016/j.bbrc.2019.08.081PMID: 31434612

  2. J Mol Cell Cardiol · 2019

    Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy

    Kluge A, Rangrez AY, Kilian LS, Pott J, Bernt A, Frauen R, Rohrbeck A, Frey N, Frank D

    DOI: 10.1016/j.yjmcc.2019.01.028PMID: 30797814

  3. Cardiovasc Res · 2019

    Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure

    Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, González Maldonado S, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer JS, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N

    DOI: 10.1093/cvr/cvy274PMID: 30418544

2017

  2. J Biol Chem · 2017

    The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling

    Dierck F, Kuhn C, Rohr C, Hille S, Braune J, Sossalla S, Molt S, van der Ven PFM, Fürst DO, Frey N

    DOI: 10.1074/jbc.M117.786764PMID: 28717008

  3. J Biol Chem · 2017

    TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels

    Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N

    DOI: 10.1074/jbc.M116.752543PMID: 28465353

  4. Biochim Biophys Acta Mol Cell Res · 2017

    Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation

    Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, Sossalla S, Frey N, Frank D

    DOI: 10.1016/j.bbamcr.2017.01.004PMID: 28087342

2016

  1. Sci Rep · 2016

    Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy

    Bernt A, Rangrez AY, Eden M, Jungmann A, Katz S, Rohr C, Müller OJ, Katus HA, Sossalla ST, Williams T, Ritter O, Frank D, Frey N

    DOI: 10.1038/srep35758PMID: 27767176

  2. Nat Commun · 2016

    Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

    Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, German Mouse Clinic Consortium, Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N

    DOI: 10.1038/ncomms11317PMID: 27122098Correction: 10.1038/ncomms11835

  3. Cardiovasc Res · 2016

    Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling

    Hille S, Dierck F, Kühl C, Sosna J, Adam-Klages S, Adam D, Lüllmann-Rauch R, Frey N, Kuhn C

    DOI: 10.1093/cvr/cvw074PMID: 27056896

  4. J Biol Chem · 2016

    Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and beta-Catenin/GSK-3beta Protein Signaling

    Rangrez AY, Eden M, Poyanmehr R, Kuhn C, Stiebeling K, Dierck F, Bernt A, Lüllmann-Rauch R, Weiler H, Kirchof P, Frank D, Frey N

    DOI: 10.1074/jbc.M115.689620PMID: 26719331

2015

  1. J Mol Cell Cardiol · 2015

    Heat-shock-protein 90 protects from downregulation of HIF-1alpha in calcineurin-induced myocardial hypertrophy

    Eschricht S, Jarr KU, Kuhn C, Lehmann L, Kreusser M, Katus HA, Frey N, Chorianopoulos E

    DOI: 10.1016/j.yjmcc.2015.05.018PMID: 26031702

2014

  1. Cardiovasc Res · 2014

    RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

    Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N

    DOI: 10.1093/cvr/cvu146PMID: 24920296

  2. J Mol Cell Cardiol · 2014

    Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy

    Frank D, Rangrez AY, Poyanmehr R, Seeger TS, Kuhn C, Eden M, Stiebeling K, Bernt A, Grund C, Franke WW, Frey N

    DOI: 10.1016/j.yjmcc.2014.03.016PMID: 24698889

2010

  1. Circ Res · 2010

    Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing

    Will RD, Eden M, Just S, Hansen A, Eder A, Frank D, Kuhn C, Seeger TS, Oehl U, Wiemann S, Korn B, Koegl M, Rottbauer W, Eschenhagen T, Katus HA, Frey N

    DOI: 10.1161/CIRCRESAHA.110.222372PMID: 20847312

2009

2008

  1. J Clin Invest · 2008

    Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation

    Frey N, Frank D, Lippl S, Kuhn C, Kögler H, Barrientos T, Rohr C, Will R, Müller OJ, Weiler H, Bassel-Duby R, Katus HA, Olson EN

    DOI: 10.1172/JCI36277PMID: 18846255

2006

  1. J Biol Chem · 2006

    Alterations of tension-dependent ATP utilization in a transgenic rat model of hypertrophic cardiomyopathy

    Frey N, Brixius K, Schwinger RH, Benis T, Karpowski A, Lorenzen HP, Luedde M, Katus HA, Franz WM

    DOI: 10.1074/jbc.M507740200PMID: 16882671

2004

  1. Nat Med · 2004

    Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

    Frey N, Barrientos T, Shelton JM, Frank D, Rütten H, Gehring D, Kuhn C, Lutz M, Rothermel B, Bassel-Duby R, Richardson JA, Katus HA, Hill JA, Olson EN

    DOI: 10.1038/nm1132PMID: 15543153

2003

2002

2000

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